Results: We identified a total of 1225 publications with citation frequency of 40511 times up to March 30, 2019. GraphPad Prism 6, and VOSviewer software were used to collect and analyze the publication trend in related field. Materials and Methods: We extracted all relevant publications with regard to sepsis and immune response during 1999-2019 from Web of Science. Our study aims to study the research trend on sepsis and host immune response, and compare the contribution of publications from different countries, institutions, journals and authors. Introduction: Sepsis is an intractable disorder, which is associated with high risk of organ dysfunction and even death, while its pathogenesis remains largely unclear. Immunosuppression related researches may be hotspots in the near future. Latest progress can be tracked in journal of Shock. There is a mismatch between the quantity and quality of publications from China.
Conclusions: The United States made the most outstanding contribution within this important field. The "immunosuppression related research" seemed to be the hotspot in relevant scope. The keyword "regulatory T cell" appeared most recently with an average appearing years of 2014.0. Ayala A SA, has published the most papers in this field (31), while Hotchkiss RS presented with the most citation frequency (3532). Journal of Shock had published most papers related to the topic on sepsis and immune response. The sum of publications from China ranked the second, while the overall citations (1935) and H-index (22) ranked the eighth and the seventh, respectively. The United States accounted for the largest number of publications (36.3%), 51.9% of total citations as well as the highest H-index (72).
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